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A measured daily routine, built on published evidence.

Four formulas, twenty-four strains, and a human trial behind every claim on this page. Two capsules in the morning, two at night.

Find your formula Read the science
Strains
24 strains
Dose
53.6 billion AFU
Testing
Third-party tested
Four Tonic jars on a pale wooden counter in morning light

Four formulas. One routine.

Each one exists because a question could be answered with a trial. Nothing is here because it tested well in a dish.

See all four

A capsule that opens where it should.

Stomach acid is the reason most of a probiotic never arrives. TN-01 uses a capsule inside a capsule: the outer shell carries the prebiotic and dissolves early, the inner core stays shut until it is past the stomach.

Cross-section, TN-01 Daily Synbiotic. Drawn to scale from the manufacturing specification. Outer shell Dissolves at pH 5.5 Prebiotic layer 400mg polyphenol Inner core 24 strains, 53.6B AFU Delayed seam Opens past the stomach
Outer shell
Dissolves at pH 5.5
Prebiotic layer
400mg polyphenol
Inner core
24 strains, 53.6B AFU
Delayed seam
Opens past the stomach

Cross-section, TN-01 Daily Synbiotic. Drawn to scale from the manufacturing specification.

A glass of water and two jars beside a window in early morning light

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Two in the morning. Two at night.

The whole routine is four capsules and about fifteen seconds. Nothing in the range competes with anything else in it, which is why the morning and night formulas were designed as one thing.

07:00 TN-01 and TN-02
Four capsules with water, before or with breakfast. The synbiotic does not need food; the multivitamin absorbs better with it.
08:30 AM-03 with your first coffee
Theanine and caffeine were studied together far more than either was alone. Take it alongside, not instead.
22:15 PM-04, forty-five minutes before bed
Glycine and magnesium need a little runway. Set it beside the light switch and it will not be the thing you forget.
Build the routine

What the trial actually found.

Every figure below comes from a registered study with a named sample size. Where an endpoint failed, it is in the paper too.

89 %
reported less bloating after twelve weeks
TN-01, n=228, randomised, placebo-controlled
11 ×
more strains survived to the colon than the uncoated control
In vitro digestion model, 2023
3.2 d
faster return to regular transit time
TN-01, n=228, versus placebo arm
24
strains, each held at the dose its own trial used
Formulation record, published in full
0
proprietary blends anywhere in the range
Every amount is printed on the jar
Read the full protocol

Members who read the label first.

  • I have taken something like this for nine years and this is the first one that printed the dose of every strain on the side of the jar. I checked three of them against the papers.

    Robin Achterberg

    Member since 2021

  • The bloating went first, around week two. The thing I did not expect was that I stopped thinking about it at all by week eight, which I suppose is the point.

    Marlowe Deane

    Member since 2022

  • PM-04 is the only sleep product I have used that does not leave me underwater the next morning. I sleep about forty minutes longer and wake up before the alarm.

    Sasha Ferreira

    Member since 2023

Written about, mostly for the parts we publish.

  • A researcher holding a jar up to daylight in a bright laboratory

  • Publishing the failed endpoints alongside the successful ones is not how this category behaves.

    The Wellcome Review

  • Two capsules held in an open palm above a wooden counter
  • Four jars on a pale shelf beside a trailing houseplant

Not sure where to start?

Four questions, one recommendation, no email required to see it.

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Close detail of a broad green leaf in low daylight

Read before you buy.

The protocol, the endpoints that failed, and the sourcing limits — all of it, in one place.

Open the evidence